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US 2013/0172372 A1Published application
Ring-fused 4-aminopyrimidines and use thereof as stimulators of soluable guanylate cyclases
AssigneeBayer Intellectual Property GmbH
InventorsMarkus Follmann, Johannes-Peter Stasch, Gorden Redlich, Jens Ackerstaff, Nils Griebenow, Andreas Knorr, Frank Wunder, Volkhart Min-Jian Li
Life of this patent
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Abstract
The present application relates to novel fused 4-aminopyrimidines, to processes for preparation thereof, to the use thereof, alone or in combinations, for treatment and/or prophylaxis of diseases and to the use thereof for production of medicaments for the treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of cardiovascular disorders.
Claims12
A compound of the formula (I)
- in which
- A is (C1-C3)-alkanediyl or a group of the formula
- where
- * is the attachment site to the pyrimidine ring,
- # is the attachment site to the carbonyl group,
- the ring Q is a 4- to 6-membered heterocycle,
- and
- where (C1-C3)-alkanediyl may be substituted by 1 or 2 substituents independently selected from the group of fluorine, trifluoromethyl, (C1-C4)-alkyl, hydroxyl and amino,
- in which (C1-C4)-alkyl may be substituted by 1 to 3 substituents independently selected from the group of fluorine, trifluoromethyl and hydroxyl,
- R1 is hydrogen or fluorine,
- R2 is (C1-C6)-alkyl or benzyl,
- where (C1-C6)-alkyl is substituted by one trifluoromethyl substituent,
- where (C1-C6)-alkyl may be substituted by 1 to 3 fluorine substituents,
- and
- where benzyl is substituted by 1 to 3 fluorine substituents,
- or N-oxides, salts, solvates, salts of the N-oxides and solvates of the N-oxides or salts thereof.
13 more elements
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Dependencies are inferred from the claim text.