Bridged heterocyclic compounds and methods of use

A compound is of the formula (F):

• where:
• R1 is H, hydroxyl, substituted or unsubstituted C1-C8 alkyl, substituted or unsubstituted C2-C8 alkenyl, substituted or unsubstituted C2-C8 alkynyl, perhaloalkyl, acyl, acyloxy, carbonylalkoxy, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted aralkyl, C1-C8 perhaloalkoxy, alkoxy, aryloxy, carboxyl, thioalkyl, substituted or unsubstituted amino, acylamino, aminoacyl, aminocarbonylamino, aminocarbonyloxy, aminosulfonyl, sulfonylamino, sulfonyl or carbonylalkylenealkoxy;
• R2 is H, substituted or unsubstituted C1-C8 alkyl, halo, cyano, hydroxyl, alkoxy or nitro;
• each R3a and R3b is independently H, substituted or unsubstituted C1-C8 alkyl, halo, cyano, nitro, hydroxyl, alkoxy, substituted or unsubstituted amino, cycloalkyl, aryl, heteroaryl, heterocyclyl, acylamino or acyloxy or R3a and R3b are taken together to form a cycloalkyl or a carbonyl moiety;
• each X7, X8, X9 and X10 is independently N or CR4;
• m and q are independently 0 or 1;
• p is 1 or 2;
• each R4 is independently H, hydroxyl, nitro, cyano, halo, C1-C8 perhaloalkyl, substituted or unsubstituted C1-C8 alkyl, substituted or unsubstituted C2-C8 alkenyl, substituted or unsubstituted C2-C8 alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, C1-C8 perhaloalkoxy, C1-C8 alkoxy, aryloxy, carboxyl, thiol, carbonylalkoxy, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aralkyl, thioalkyl, substituted or unsubstituted amino, acylamino, aminoacyl, aminocarbonylamino, aminocarbonyloxy, aminosulfonyl, sulfonylamino, sulfonyl, carbonylalkylenealkoxy, alkylsulfonylamino or acyl;
• each R8a, R8b, R8c and R8d is independently H, hydroxyl, alkoxy, halo, substituted or unsubstituted C1-C8 alkyl, substituted or unsubstituted C3-C8cycloalkyl, substituted or unsubstituted C2-C8alkenyl, C1-C8 perhaloalkyl, carboxyl, carbonylalkoxy, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or is taken together with a geminal R8(a-d) to form a substituted or unsubstituted methylene moiety or a moiety of the formula —OCH2CH2O—, or is taken together with a geminal R8(a-d) and the carbon to which they are attached to form a carbonyl moiety or a cycloalkyl moiety;
• R10 is H, halo, a substituted or unsubstituted C1-C8 alkyl, hydroxyl, alkoxy, cyano or nitro;
• each R11 and R12 is independently H, halo, alkoxy, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted C1-C8 alkyl, substituted or unsubstituted C2-C8 alkenyl, substituted or unsubstituted C3-C8 cycloalkyl, carboxy, carbonylalkoxy or C1-C8 perhaloalkyl and the bond indicates the presence of either an E or Z double bond configuration, or R11 and R12 are taken together to form a bond;
• Q is substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted C3-C8 cycloalkyl, substituted or unsubstituted C3-C8 cycloalkenyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted amino, alkoxy, aminoacyl, acyloxy, carboxyl, carbonylalkoxy, cyano, alkynyl, aminocarbonylalkoxy or acylamino;
• provided that when X7-X10 is CR4, and each R2, R3a, R3b and R10 is H, then (i) at least one of R8(a-d) is hydroxyl or alkoxy, and/or (ii) at least one of R11 or R12 is alkyl or alkoxy and/or (iii) Q is other than a substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl or heterocyclyl;
• or a salt or solvate thereof.

A compound of the formula (F-1):

• where:
• R1 is H, hydroxyl, substituted or unsubstituted C1-C8 alkyl, substituted or unsubstituted C2-C8 alkenyl, substituted or unsubstituted C2-C8 alkynyl, perhaloalkyl, acyl, acyloxy, carbonylalkoxy, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted aralkyl, C1-C8 perhaloalkoxy, alkoxy, aryloxy, thioalkyl, substituted or unsubstituted amino, acylamino, aminoacyl, aminocarbonylamino, aminocarbonyloxy, aminosulfonyl, sulfonylamino, sulfonyl or carbonylalkylenealkoxy;
• each R2 and R10 is independently H, hydroxyl, alkoxy or substituted or unsubstituted C1-C8 alkyl;
• each R3a and R3b is independently H, substituted or unsubstituted C1-C8 alkyl, halo, cyano, nitro, hydroxyl, alkoxy, substituted or unsubstituted amino, cycloalkyl, aryl, heteroaryl, heterocyclyl, acylamino or acyloxy or R3a and R3b are taken together to form a cycloalkyl or a carbonyl moiety;
• p is 1 or 2;
• each X7, X8, X9 and X10 is independently N or CR4;
• each R4 is independently H, hydroxyl, nitro, cyano, halo, C1-C8 perhaloalkyl, substituted or unsubstituted C1-C8 alkyl, substituted or unsubstituted C2-C8 alkenyl, substituted or unsubstituted C2-C8 alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, C1-C8 perhaloalkoxy, C1-C8 alkoxy, aryloxy, carboxyl, thiol, carbonylalkoxy, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aralkyl, thioalkyl, substituted or unsubstituted amino, acylamino, aminoacyl, aminocarbonylamino, aminocarbonyloxy, aminosulfonyl, sulfonylamino, sulfonyl, carbonylalkylenealkoxy, alkylsulfonylamino or acyl;
• each R11 and R12 is independently H, halo, alkoxy, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted C1-C8 alkyl, substituted or unsubstituted C2-C8 alkenyl, substituted or unsubstituted C3-C8 cycloalkyl, carboxy, carbonylalkoxy or C1-C8 perhaloalkyl and the bond indicates the presence of either an E or Z double bond configuration, or R11 and R12 are taken together to form a bond;
• and
• Q is substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted C3-C8 cycloalkyl, substituted or unsubstituted C3-C8 cycloalkenyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted amino, alkoxy, aminoacyl, acyloxy, carboxyl, carbonylalkoxy, cyano, alkynyl, aminocarbonylalkoxy or acylamino;
• provided that when X7-X10 is CR4, and each R2, R3a, R3b and R10 is H then (i) at least one of R11 or R12 is alkyl or alkoxy, and/or (ii) Q is other than a substituted or unsubstituted aryl or heteroaryl.
• or a salt thereof.