Back to results
US 2013/0172364 A1Published application
Propargyl-trifluoromethoxy-aminobenzothiazole derivatives, their preparation and use
AssigneeTeva Pharmaceutical Industries Ltd.
InventorsEliezer Falb, Jeffrey Sterling, Yaacov Herzig, Raphael Nudelman, Konstantin Ulanenko
Life of this patent
Estimating the term…
Abstract
Disclosed are novel derivatives of propargyl-trifluoromethoxy-amino-benzothiazole which are effective in treating neurologic disorders, including Parkinson's disease and multiple sclerosis.
Claims20
A compound according to the formula:
- wherein R1 is —CH2NR2— or an N-containing heterocycloalkyl,
- wherein R2 is H or C1-C4 alkyl,
- or a pharmaceutically acceptable salt thereof.
A process of preparing a compound having the structure:
- comprising the steps of:
- a) reacting
- under suitable conditions with an halide acid in the presence of a first solvent;
- b) adding piperazine to the reaction mixture of step a) to provide
- c) reacting the product from step b) with propargylhalide in the presence of a second solvent;
- and
- d) obtaining the compound from the reaction mixture of step c).
4 more elements
A process of manufacturing a compound having the structure:
- wherein R is H or C1-C4 alkyl,
- comprising the steps of:
- a) reacting
- under suitable conditions with Lawesson's Reagent in the presence of a first solvent to provide
- b) reacting the product from step a) with an oxidizing agent in the presence of a second solvent to provide
- c) reacting the product from step b) with N-bromosuccinimide in the presence of a third solvent to provide
- and
- d) reacting the product from step c) with
- in the presence of a fourth solvent;
- and
- e) obtaining the compound from the reaction mixture of step d).
8 more elements
Dependencies are inferred from the claim text.