Novel benzenesulfonamide compounds, method for synthesizing same, and use thereof in medicine as well as in cosmetics

A compound of formula (I) below:

• in which:
• R1 represents a —SO2—R4 radical, with R4 having the meanings given hereinafter;
• R2 is a hydrogen atom;
• R3 is a substituted heteroaryl radical;
• R4 is an alkyl radical;
• and,
• n is 1;
• and salts thereof, and enantiomers thereof.

A method of treating a disease, disorder, or condition involving TNFα production, wherein the method comprises administering a pharmaceutical composition to a subject, to inhibit the production of TNFα in the subject, wherein the pharmaceutical composition comprises a compound having the structure of formula (I), a salt thereof, or an enantiomer thereof, and a pharmaceutically acceptable carrier,

• in which:
• R1 represents a hydrogen, an alkyl radical, a substituted alkyl radical, an alkenyl radical, a substituted alkenyl radical, an alkynyl radical, a substituted alkynyl radical, an aralkyl radical, a substituted aralkyl radical, a heteroaralkyl radical, a substituted heteroaralkyl radical, a —C(O)—R4 radical, a —SO2—R4 radical, or a C(O)OR4 radical, with R4 having the meanings given hereinafter;
• R2 is a hydrogen atom or a lower alkyl radical;
• R3 is an alkyl radical, a substituted alkyl radical, an alkenyl radical, a substituted alkenyl radical, an alkynyl radical, a substituted alkynyl radical, an aryl radical, a substituted aryl radical, an aralkyl radical, a substituted aralkyl radical, a heterocyclic radical, a substituted heterocyclic radical, a cycloalkyl radical, a substituted cycloalkyl radical, a heteroaryl radical, a substituted heteroaryl radical, a heteroaralkyl radical, or a substituted heteroaralkyl radical;
• R4 is an alkyl radical, a substituted alkyl radical, an alkenyl radical, a substituted alkenyl radical, an alkynyl radical, a substituted alkynyl radical, an aryl radical, a substituted aryl radical, an aralkyl radical, or a substituted aralkyl radical;
• and,
• n can take the values of 0, 1, 2 or 3.