Sulfur-containing compound, method of preparation and pharmaceutical uses thereof
AssigneeNational Sun Yat-Sen University
InventorsJyh-Horng SHEU, Chih-Hua CHAO, Zhi-Hong WEN
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Abstract
The invention relates to a sulfur-containing compound and the preparation thereof. The invention also relates to the uses of the sulfur-containing compound in inhibiting inducible nitric oxide synthase and/or cyclooxygenase-2 and in treating the diseases associated with inducible nitric oxide synthase and/or cyclooxygenase-2. This invention also describes a series of chemical analogues of the said sulfur-containing compound and the preparation of these compounds.
Claims10
A method for inhibiting inducible nitric oxide synthase and/or cyclooxygenase-2 comprising administering a subject with a compound represented by the following general formula 1,
- wherein:
- R1 is selected from the group consisting of H, R5 and R5C(═O);
- R2 is selected from the group consisting of S and (O═)S(═O);
- R3 is selected from the group consisting of H, CH3 and CH2CH2C(═O)OR5;
- R4 is selected from the group consisting of R5, OR5,
- N(R5)2, NH2, NHR5 and OH;
- and
- R5 is selected from an alkyl group having one to six carbon atoms and an unsubstituted or substituted phenyl group;
- provided that when R3 is CH2CH2C(═O)OR5, R4 is OR5;
- and
- when R1 is H, R2 is S and R3 is H, R4 is not CH3.
A method for treating a disease associated with inducible nitric oxide synthase and/or cyclooxygenase-2 comprising administering a subject with a compound represented by the following general formula 1,
- wherein:
- R1 is selected from the group consisting of H, R5 and R5C(═O);
- R2 is selected from the group consisting of S and (O═)S(═O);
- R3 is selected from the group consisting of H, CH3 and CH2CH2C(═O)OR5;
- R4 is selected from the group consisting of R5, OR5,
- N(R5)2, NH2, NHR5 and OH;
- and
- R5 is selected from an alkyl group having one to six carbon atoms and an unsubstituted or substituted phenyl group;
- provided that when R3 is CH2CH2C(═O)OR5, R4 is OR5;
- and
- when R1 is H, R2 is S and R3 is H, R4 is not CH3.
Dependencies are inferred from the claim text.