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US 2013/0172346 A1Published application
Use of kynurenic acid amide derivatives for the treatment of huntington's disease
OwnerLászló Vécsei, Dénes Zádori +7inventors
InventorsLászló Vécsei, Dénes Zádori, Péter Klivényi, Ferenc Fülöp, István Szatmári, József Toldi, Tamás Freund, Gábor Nyiri, András Szönyi
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Abstract
The invention is directed to kynurenic acid analogues and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing said compounds for treating the symptoms of Huntington's disease and preventing the development of the symptoms.
Claims12
A KYNA amide analog compound of the general formula (1),
- wherein the substituents are as follows:
- n stands for 1, 2, 3, or 4
- R1, R2 stand independently of each other for straight or branched alkyl containing 1 to 6 carbon atoms, or they form together with the nitrogen of the ring a 5-8 membered ring, comprising optionally as a further heteroatom another nitrogen or oxygen, wherein said ring may optionally be substituted by an alkyl containing 1 to 6 carbon atoms
- and pharmaceutically acceptable acid addition salts thereof,
- for use in the treatment of the symptoms of Huntington's disease and for preventing the development of said symptoms.
2 more elements
Dependencies are inferred from the claim text.