Chemokine Receptor Modulators

A compound of Formula I:

• or a pharmaceutically acceptable salt, solvate, tautomer, stereoisomer, and/or ester thereof, wherein:
• R1 and R2 are each independently H, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted heteroalkyl including alkoxyalkyl, haloalkyl, CF3, halogen, hydroxy, amino, optionally substituted alkyl or dialkyl amino, optionally substituted alkoxy, hydroxyalkyl, optionally substituted aminoalkyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted arlakyl, optionally substituted arylakyl, carboxy, acyl, optionally substituted alkoxycarbonyl, or optionally substituted aminocarbonyl;
• or
• R1 and R2, taken together with the carbon atoms to which they are shown attached, form a substituted or unsubstituted carbocyclyl or a substituted or unsubstituted heterocyclyl;
• M is H or -G-L3-Z;
• E is H, —W-J-L2-Y,
• L1, L2, and L3 are each independently selected from the group consisting of a covalent bond, substituted or unsubstituted alkylene, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocycyl, and substituted or unsubstituted heterocyclyl;
• X, Y and Z are independently H, NRaRb, —ORc, halogen, CF3, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, acyl, carboxy, optionally substituted alkoxycarbonyl, optionally substituted aminocarbonyl, optionally substituted alkyl- or dialkylaminocarbonyl, cyano, optionally substituted heterocyclylacyl, optionally substituted carbocyclylacyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl;
• Ra and Rb are each independently selected from the group consisting of H, substituted or unsubstituted alkyl, aldiminyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted carbocyclylalkyl, substituted or unsubstituted heterocyclylalkyl, and substituted or unsubstituted heterocyclyl;
• or
• Ra and Rb, together with the nitrogen atom to which they are shown attached form a substituted or unsubstituted heterocyclyl;
• Rc is selected from the group consisting of H, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted carbocyclylalkyl, substituted or unsubstituted heterocyclylalkyl,
• J is selected from the group consisting of a covalent bond, alkylene, —C(O)—NRd—, —C(O)—O—, —NRd—, and —C(O)—;
• Rd is selected from the group consisting of H, alkyl, and substituted or substituted arylalkyl;
• Q is CRe or N;
• Re is selected from the group consisting of H, alkyl, halo, substituted or unsubstituted amino, cyano, nitro, haloalkyl, hydroxyl, and alkoxyl;
• G is selected from the group consisting of a covalent bond, alkylene, —C(O)—, —C(O)—O—, and —C(O)—NRd—;
• W is selected from the group consisting of a covalent bond and a substituted or unsubstituted heterocyclyl;
• R3 and R4 are each independently selected from the group consisting of H, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, and substituted or unsubstituted alkynyl;
• or
• R3 and R4, taken together with the carbon atoms to which they are shown attached, form a substituted or unsubstituted carbocyclyl or a substituted or unsubstituted heterocyclyl;
• R5 and R6 are each independently selected from the group consisting of substituted or unsubstituted aminoalkyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted carbocyclylalkyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted heterocyclylalkyl, alkyl, alkenyl, and alkynyl;
• or
• -L2-Y and R6, together with the atoms to which they are shown attached form a fused substituted or unsubstituted ring;
• or
• E and -L1X, together with the atoms to which they are shown bonded form a substituted or unsubstituted heterocyclyl;
• R7 is selected from the group consisting of H, substituted or unsubstituted alkyl, substituted or unsubstituted aminoalkyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted carbocyclylalkyl, and substituted or unsubstituted heterocyclylalkyl;
• or
• L2Y and R7 together with the atoms to which they are shown bonded form a fused substituted or unsubstituted ring;
• and
• A and B are each independently one or more substituents selected from the group consisting of H, alkyl, halo, substituted or unsubstituted amino, cyano, nitro, haloalkyl, hydroxyl, and alkoxyl;
• with the proviso that only one of M, E and L1X is H.