Substituted n- [1-cyano-2- (phenyl) ethyl] -2-azabicyclo [2.2.1] heptane-3-carboxamide inhibitors of cathepsin c

A compound of the formula I

• wherein
• n is 0, 1, 2, 3 or 4;
• R1 is C1-6-alkyl-, halogen, HO—, C1-6-alkyl-O—, H2N—, (C1-6-alkyl)2N—, C1-6-alkyl-C(O)HN—;
• R2 is H, halogen or selected from the group consisting of
• C1-6-alkyl-, C2-6-alkenyl-, C2-6-alkinyl-, C3-6-cycloalkyl- or C3-6-cycloalkenyl- each optionally substituted independently from each other with one, two, three or four R2.1;
• a monocyclic C5-7-heterocyclyl-, wherein one or two carbon atoms are replaced by heteroatoms selected from —S—, —S(O)—, —S(O)2—, —O— or —N— and the ring is fully or partially saturated, optionally substituted independently from each other with one, two, is three or four R2.1;
• a bicyclic C8-10-heterocyclyl-, wherein one, two, three or four carbon atoms are replaced by heteroatoms selected from —S—, —S(O)—, —S(O)2—, —O— or —N— and the ring is fully or partially saturated, optionally substituted independently from each other with one, two, three or four R2.1;
• a C5-10-heteroaryl-, wherein one, two, three or four carbon atoms are replaced by heteroatoms selected from —S—, —S(O)—, —S(O)2—, —O— or —N— and the ring is aromatic, optionally substituted independently from each other with one, two, three or four R2.1;
• aryl-, optionally substituted independently from each other with one, two, three or four R2.1;
• aryl-(O)C—HN—, optionally substituted independently from each other with one, two, three or four R2.1;
• R2.1 is halogen, C1-6-alkyl-, C3-6-cycloalkyl-, HO—, O═, C1-6-alkyl-O—, C1-6-alkyl-(O)C—, C1-6-alkyl-O(O)C—, C1-6-alkyl-HN—, (C1-6-alkyl)2N—, C1-6-alkyl-S—, C1-6-alkyl-(O)S—, C1-6-alkyl-(O)2S—, C1-6-alkyl-(O)2SO—, (C1-6-alkyl)2N(O)C—, C1-6-alkyl-HN(O)C—, C1-6-alkyl-(O)CHN—, C1-6-alkyl-(O)C(C1-6-alkyl)N—, C3-6-cycloalkyl-HN—, C3-6-cycloalkyl-(O)C—, HO—C1-6-alkyl-, MeO—C1-6-alkyl-, NC—, (C1-6-alkyl)2N(O)2S—, C1-6-alkyl-HN(O)2S—, (C1-6-alkyl)2(HO)C— or R2.1.1—, R2.1.1—C1-6-alkyl-O(O)C—,
• R2.1.1 is phenyl-, pyridinyl-, C3-6-cycloalkyl-, each optionally substituted with one, two or three halogen, HO—, NC—, C1-6-alkyl-, C1-6-alkyl-O—;
• or a salt thereof.