Azetidine Derivatives

A compound of the formula I

• wherein
• Ar1 is selected from a group consisting of:
• 6- to 10-membered arylene and 5- to 10-membered heteroarylene all of which may be optionally substituted with one or more substituents RA, wherein R1 and RA linked to adjacent C-atoms of Ar1 may be connected with each other and together form a C3-5-alkylene bridging group in which 1, 2 or 3 —CH2— groups may be replaced by O, C(═O), S, S(═O), S(═O)2, NH or N(C1-4-alkyl)-, wherein the alkylene bridge may optionally be substituted by one or two C1-3-alkyl groups;
• RA is selected from a group consisting of:
• H, F, Cl, Br, I, CN, OH, —NO2, C2-4-alkenyl, C1-4-alkyl-C(═O)—, H2N—, H2N—C(═O)—, H2N—S(═O)2—, HO—C(═O)—, C1-4-alkyl-O—C(═O)—, phenyl and phenyl-C1-3-alkyl,
• wherein in each NH2— group, one or both hydrogen atoms may independently be replaced by C1-4-alkyl;
• wherein each alkyl and cycloalkyl may be optionally substituted with one or more F atoms;
• R1 is selected from a group consisting of:
• H, OH, C1-6-alkyl, C3-7-cycloalkyl, C3-7-cycloalkyl-O—, C3-7-cycloalkyl-C1-3-alkyl-O—, H2N—, (C1-4-alkyl)NH—, (C1-4-alkyl)2N—, C3-7-cycloalkyl-NH—, C3-7-cycloalkyl-N(C1-4-alkyl)-, C3-7-cycloalkyl-C1-3-alkyl-NH—, (C3-7-cycloalkyl-C1-3-alkyl)-N(C1-4-alkyl)-, C1-4-alkyl-C(═O)—, C1-4-alkyl-S(═O)2—, HO—C(═O)—, C1-4-alkyl-O—C(═O)—, H2N—C(═O)—, (C1-4-alkyl)HN—C(═O)—, (C1-4-alkyl)2N—C(═O)—, aryl, aryl-C1-3-alkyl-, aryl-C1-3-alkyl-O—, heterocyclyl, heterocyclyl-O—, heterocyclyl-C1-3-alkyl-O—, heteroaryl, heteroaryl-C1-3-alkyl- and heteroaryl-C1-3-alkyl-O—,
• wherein each alkyl and cycloalkyl may be optionally substituted with one or more substituents selected from F, OH and C1-4-alkyl-O—, and
• wherein each heterocyclyl is optionally substituted with one or more C1-3-alkyl;
• Ar2 is selected from a group consisting of:
• phenylene and a 5- or 6-membered monocyclic heteroaryl containing 1, 2 or 3 heteroatoms selected from N, O, or S,
• wherein all of the before mentioned groups may be optionally substituted with one or more substituents RA;
• R2a and R2b are each independently selected from a group consisting of:
• H and C1-3-alkyl;
• R3 is selected from a group consisting of:
• H and C1-4-alkyl;
• and
• R4 is selected from a group consisting of:
• H, C1-6-alkyl, C3-10-carbocyclyl, C3-10-carbocyclyl-C1-3-alkyl-, C2-6-alkenyl, O2-6-alkynyl, C1-6-alkyl-O—, RN1RN2N, heterocyclyl, heterocyclyl-C1-3-alkyl, aryl, aryl-C1-3-alkyl, heteroaryl and heteroaryl-C1-3-alkyl,
• wherein in each carbocyclyl and heterocyclyl a —CH2— group may optionally be replaced by —C(═O)—, and
• wherein each alkyl, carbocyclyl, heterocyclyl, aryl and heteroaryl group may be optionally substituted with one or more substituents independently selected from the group R5;
• while
• RN1 is selected from a group consisting of:
• H and C1-4-alkyl;
• wherein each alkyl group may be optionally substituted with one R5;
• RN2 is selected from a group consisting of:
• H, C1-4-alkyl, C3-10-carbocyclyl, C3-10-carbocyclyl-C1-3-alkyl, C2-6-alkenyl, C2-6-alkynyl, heterocyclyl, heterocyclyl-C1-3-alkyl, aryl, aryl-C1-3-alkyl, heteroaryl and heteroaryl-C1-3-alkyl,
• wherein each carbocyclyl and heterocyclyl may be optionally substituted with one or more C1-4-alkyl, aryl or aryl-C1-3-alkyl-, and
• wherein in each carbocyclyl and heterocyclyl a CH2— group may optionally be replaced by —C(═O)—;
• and
• with the provision that there is at least one CH2— group between any double or triple bond of the alkenyl and alkynyl groups and the nitrogen atom to which they are attached and
• R5 is selected from a group consisting of:
• F, Cl, Br, CN, OH, C1-4-alkyl-, C1-4-alkyl-O—, C1-4-alkyl-S—, C1-4-alkyl-S(═O)2—, H2N—, (C1-4-alkyl)NH—, (C1-4-alkyl)2N—, C1-4-alkyl-(C═O)—NH—, heterocyclyl and aryl,
• wherein each alkyl may be optionally substituted with one or more F-atoms and/or with a substituent selected from OH, C1-3-alkyl-O— and CN;
• and
• wherein two substituents R5 attached to an aryl or heteroaryl group may be linked to each other and form a C2-5-alkylene bridging group in which one or two —CH2— groups may be replaced by a group independently of each other selected from O, S, NH and N(C1-4-alkyl)-, wherein the C2-5-alkylene bridging group is optionally be substituted by one or two C1-3-alkyl groups or F atoms;
• or a tautormer or pharmaceutically acceptable salt thereof.