US 2013/0172311 A1 · Substituted heterocyclyl benzyl pyrazoles, and use thereof

Abstract

The present application relates to novel substituted 1-[3-(heterocyclyl)benzyl]-1H-pyrazole derivatives, to processes for preparation thereof, to use thereof for treatment and/or prevention of diseases and to use thereof for production of medicaments for treatment and/or prevention of diseases, more particularly for treatment and/or prevention of hyperproliferative and angiogenic diseases and those diseases which arise from metabolic adaptation to hypoxic states. Such treatments can be effected in the form of monotherapy or else in combination with other medicaments or further therapeutic measures.

Claims19

Dependent claims

A compound of the formula (I)

in which
m is 1 or 2,
n is 1, 2 or 3,
R1 is hydroxyl or cyano,
and
R2 is trifluoromethoxy, trifluoromethylsulphanyl, trifluoromethylsulphonyl, pentafluorosulphanyl or a group of the formula
in which
denotes the bonding site to the phenyl ring,
R3A and R3B are each independently fluorine or methyl
or
are joined to one another and, together with the carbon atom to which they are bonded, form a cyclopropane-1,1-diyl, cyclobutane-1,1-diyl, cyclopentane-1,1-diyl, cyclohexane-1,1-diyl, oxetane-3,3-diyl or tetrahydro-2H-pyran-4,4-diyl ring
and
R4 is hydrogen, fluorine, methyl, trifluoromethyl or methoxy,
and the salts, solvates and solvates of the salts thereof.

11 more elements

Dependencies are inferred from the claim text.

Substituted heterocyclyl benzyl pyrazoles, and use thereof

Life of this patent

Substituted heterocyclyl benzyl pyrazoles, and use thereof

Life of this patent

Abstract

Claims19