Benzamides and related inhibitors of factor xa
AssigneeMillennium Pharmaceuticals, Inc.
InventorsBing-Yan Zhu, Penglie Zhang, Lingyan Wang, Wenrong Huang, Erick A. Goldman, Wenhao Li, Jingmei Zuckett, Yonghong Song, Robert M. Scarborough
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Abstract
Novel benzamide compounds including their pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug derivatives having activity against mammalian factor Xa are described. Compositions containing such compounds are also described. The compounds and compositions are useful in vitro or in vivo for preventing or treating coagulation disorders.
Claims12
-72. (canceled)
A compound of the formula:
- wherein:
- R1a is H or —F;
- R1d3 is H or —OCH3;
- R1d3 is selected from the group consisting of H, —F, —Cl, —Br, —OCH3 and —OCF3;
- R1e is selected from the group consisting of H, —F, —Cl and —Br;
- and
- A-Q is selected from the group consisting of:
- or a pharmaceutically acceptable salt thereof.
A compound of the formula
- or a pharmaceutically acceptable salt thereof.
A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound of the formula:
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.