Back to results
US 2013/0172296 A1Published application
Method of activation of oxazaphosphorines
AssigneeDuke University
InventorsIvan Spasojevic, Michael O. Colvin, Ines Batinic-Haberle, Susan M. Ludeman, Michael P. Gamcsik
Life of this patent
Estimating the term…
Abstract
The present invention provides a method of hydroxylating or oxidizing a compound of interest in a subject (e.g., a cytotoxic oxazaphosphorine prodrug), by administering the compound of interest to the subject; and concurrently administering the subject a metalloporphyrin in an amount effective to hydroxylate or oxidize the compound of interest in the subject.
Claims11
In a method of treating a subject in need thereof with a cytotoxic oxazaphosphorine prodrug, the improvement comprising:
- concurrently administering said subject a metalloporphyrin in an amount effective to enhance the efficacy of said oxazaphosphorine in said subject.
11-16. (canceled)
Dependencies are inferred from the claim text.