Linked purine pterin hppk inhibitors useful as antibacterial agents

A compound or pharmaceutically acceptable salt thereof of the formula:

• wherein:
• is a 5 or 6-membered heterocyclic ring;
• X is nitrogen, —N(A5)-, —C(A6)-, or —C(A6A7)-;
• A1 is hydrogen, oxo, amino, or aminoC1-C2alkyl;
• A2 is absent, hydrogen, or C1-C2alkyl;
• A3 is absent, or one or two substituents independently chosen from hydrogen, halogen, C1-C2alkyl, and C1-C2alkoxy;
• A5 is hydrogen or C1-C4alkyl;
• A6 and A7 are independently hydrogen, C1-C4alkyl, or C1-C4alkoxy;
• R1 is methylene optionally substituted with hydroxyl, halogen, C1-C2alkyl, or oxo;
• R2 is chosen from —NH—, —SH—, —S(═O)—, —S(═O)2—, —P(═O)—, and —P(═O)2—;
• L1 is an alkylene linker having from 1 to 4 carbon atoms, optionally containing 1 heteroatom selected from oxygen, nitrogen, and sulfur, and optionally containing 1 to 2 carbon-carbon double bonds, wherein L1 is unsubstituted or substituted with 1 or more substituents independently chosen from hydroxyl, halogen, amino, C1-C4alkyl, C1-C4alkoxy, C1-C2haloalkyl, and C1-C2haloalkoxy;
• R3 is absent or R3 is an amide, heteroalkylene, cycloalkyl, heterocycloalkyl, phenyl, or 5- or 6-membered heteroaryl;
• and R3 is unsubstituted or substituted with 1 or more substituents independently chosen from hydroxyl, halogen, amino, C1-C4alkyl, C1-C4alkoxy, mono- and di-C1-C4alkylamino, C1-C2haloalkyl, and C1-C2haloalkoxy;
• L2 is absent or L2 is an alkylene linker having from 1 to 4 carbon atoms, optionally containing 1 heteroatom selected from oxygen, nitrogen, sulfur, and phosphorus and optionally containing 1 to 2 carbon-carbon double bonds, wherein L2 is unsubstituted or substituted with 1 or more substituents independently chosen from oxo, hydroxyl, halogen, amino, C1-C4alkyl, C1-C4alkoxy, C1-C2haloalkyl, and C1-C2haloalkoxy;
• R4 is a 5- or 6-membered monosaccharide ring or R1 is an alkylene or heteroalkylene linker having from 1 to 4 chain atoms;
• and
• B1 and B2 are independently chosen from hydrogen, halogen, hydroxyl, amino, C1-C2alkyl, C1-C2alkoxy, mono- or di-C1-C2alkylamino, aminoC1-C2alkyl, C1-C2haloalkyl, and C1-C2haloalkoxy.