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US 2013/0172274 A1Published application
Methods and compositions for delivering active agents with enhanced pharmacological properties
AssigneeDuke University
InventorAshutosh Chilkoti
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Abstract
Provided herein are methods of enhancing in vivo efficacy of an active agent, comprising: administering to a subject an active agent that is coupled to a bioelastic polymer or elastin-like peptide, wherein the in vivo efficacy of the active agent is enhanced as compared to the same active agent when administered to the subject not coupled to (or not associated with) a bioelastic polymer or ELP.
Claims8
A method of enhancing in vivo efficacy of a peptide agent, comprising:
- administering to a subject the peptide agent as a fusion with an amino acid sequence having a pattern of proline-containing beta-turns forming an extended, non-globular structure,
- the peptide fusion protein being administered about once per week, about once every two weeks, or about monthly.
Dependencies are inferred from the claim text.