Lyophilized recombinant vwf formulations

A stable lyophilized pharmaceutical formulation of a recombinant von Willebrand Factor (rVWF) comprising:

• (a) a rVWF;
• (b) one or more buffering agents;
• (c) one or more amino acids;
• (d) one or more stabilizing agents;
• and (e) one or more surfactants;
• said rVWF comprising a polypeptide selected from the group consisting of:
• a) the amino acid sequence set out in SEQ ID NO:
• 3;
• b) a biologically active analog, fragment or variant of a);
• c) a polypeptide encoded by the polynucleotide set out in SEQ ID NO:
• 1;
• d) a biologically active analog, fragment or variant of c);
• and
• e) a polypeptide encoded by a polynucleotide that hybridizes to the polynucleotide set out in SEQ ID NO:
• 1 under moderately stringent hybridization conditions;
• said buffer is comprising of a pH buffering agent in a range of about 0.1 mM to about 500 mM and said pH is in a range of about 2.0 to about 12.0;
• said amino acid is at a concentration of about 1 to about 500 mM;
• said stabilizing agent is at a concentration of about 0.1 to about 1000 mM;
• and
• said surfactant is at a concentration of about 0.01 g/L to about 0.5 g/L.