Use of cyclic depsipeptides to inhibit kallikrein 7

Method of treating a subject suffering from a kallikrein 7-dependent disease, comprising:

• administering to said subject a therapeutically effective amount of a cyclic depsipeptide, or a derivative thereof, having the structure of formula (I):
• wherein the ester bond is found between the carboxy group of A7 and the hydroxy group of A2,
• wherein X and A1 are each independently optional,
• and wherein
• X is any chemical residue
• A1 is a standard amino acid,
• A2 is threonine or serine or 5-methylhydroxyproline,
• A3 is a non-basic standard amino acid or a non-basic non-standard amino acid, or a non-basic derivative thereof,
• A4 is Ahp, dehydro-AHP, proline or a derivative thereof,
• A5 is isoleucine, leucine, phenylalanin, prolin, threonine, or valine,
• A6 is alanine, phenylalanine, tryptophan, tyrosine or a derivative thereof
• A7 is leucine, isoleucine or valine,
• wherein the nitrogen atom of the amid bond between A5 and A6 can be substituted with a methyl
• or a pharmaceutically acceptable salt of cyclic depsipeptide or a derivative thereof.