Methods and Compositions for Inhibiting Tumor Cell Proliferation
AssigneeThe Board of Trustees of the University of Illinois
InventorsPradip Raychaudhuri, Alexander V. Lyubimov, Robert Costa, Zebin Wang
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Abstract
The invention provides agents, compositions, pharmaceutical compositions and method for inhibiting tumor cell proliferation by inhibiting FoxM1B activity, expression, or nuclear localization in a tumor cell.
Claims13
A polypeptide that inhibits FoxM1B activity in a tumor cell, said polypeptide comprising (1) a p19Arf peptide fragment comprising p19Arf amino acid residues 26-44 of SEQ ID NO:16, and (2) an HIV Tat peptide of SEQ ID NO:17 or a nine-D-Arg peptide of SEQ ID NO:18 that is covalently linked to the N-terminus of the p19Arf peptide fragment, wherein the polypeptide is modified at the N-terminus, at the C-terminus or at both the N terminus and the C terminus.
Dependencies are inferred from the claim text.