Compound and method for treatment of alzheimer's disease and familial dementia
AssigneeAlphabeta AB
InventorJan Johansson
Life of this patent
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Abstract
An isolated protein is provided for use in treatment of a condition selected from the group consisting of Alzheimer's disease, familial Danish dementia and familial British dementia in a mammal, including man. The isolated protein is selected from the group consisting of proteins comprising an amino acid sequence having at least 70% identity to residues 90-236 of Bri2 from human; and proteins comprising an amino acid sequence having at least 70% identity to any one of the Brichos domains of Bri2 from human, chimpanzee, bovine, pig, mouse and rat.
Claims22
An isolated protein selected from the group of proteins consisting of residues 90-236 of Bri2 from human (SEQ ID NO:
- 2) and the Brichos domains of Bri2 from human (SEQ ID NO:
- 5), chimpanzee (SEQ ID NO:
- 6), bovine (SEQ ID NO:
- 7), pig (SEQ ID NO:
- 8), mouse (SEQ ID NO:
- 9) and rat (SEQ ID NO:
- 10).
5-9. (canceled)
11-13. (canceled)
A method for treating a condition selected from the group consisting of Alzheimer's disease, familial Danish dementia and familial British dementia in a mammal in need thereof, the method comprising administering to said mammal a therapeutically effective amount of an isolated protein selected from the group consisting of proteins comprising an amino acid sequence having at least 70% identity to residues 90-236 of Bri2 from human (SEQ ID NO:
- 2);
- and proteins comprising an amino acid sequence having at least 70% identity to any one of the Brichos domains of Bri2 from human (SEQ ID NO:
- 5), chimpanzee (SEQ ID NO:
- 6), bovine (SEQ ID NO:
- 7), pig (SEQ ID NO:
- 8), mouse (SEQ ID NO:
- 9) and rat (SEQ ID NO:
- 10);
- with the provisos that said protein is not comprising an amino acid sequence having at least 70% identity to residues 1-89 of Bri2 from human (SEQ ID NO:
- 3);
- and said protein is not comprising an amino acid sequence having at least 70% identity to human ABri23 (SEQ ID NO:
- 4).
21-26. (canceled)
Dependencies are inferred from the claim text.