Multimeric tie 2 agonists and uses thereof in stimulating angiogenesis
AssigneeSunnybrook Health Sciences Center
InventorsPaul Van Slyke, Daniel Dumont
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Abstract
The present invention provides a multimeric form of a Tie 2 binding peptide monomer, wherein the multimeric form has Tie 2 agonist activity. The multimeric form, preferably a tetramer, stimulates angiogenesis and promotes wound healing. The present invention also features pharmaceutical compositions comprising the multimeric Tie 2 agonists, including those suitable for topical or systemic administration. Methods of using the multimeric Tie 2 agonists of the invention for stimulating angiogenesis and for promoting healing of wounds, such as diabetic ulcers or skin grafts, are also provided.
Claims31
1-79. (canceled)
A composition comprising a multimeric form of a Tie 2 binding peptide monomer, wherein the multimeric form has Tie 2 agonist activity.
A composition comprising a Tie 2 binding peptide monomer, the Tie 2 binding peptide monomer comprising a structure A-B-C, wherein:
- A comprises a Tie 2 binding peptide;
- B comprises a spacer;
- and
- C comprises a multimerizing group.
Dependencies are inferred from the claim text.