Extract for Preventing of Treating Thrombotic Diseases
AssigneeMudanjiang Youbo Pharmaceutical Co., LTD.
InventorZhenguo Li
Life of this patent
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Abstract
An extract for preventing or treating thrombotic diseases, particularly, an extract of at least one of leeches and earthworms having a molecular weight of no more than 5,800 daltons is provided, wherein the extract includes 15% to 38% amino acid, 40% to 60% saccharide and 0.3% to 1% hypoxanthine. Processes for preparation, pharmaceutical compositions and uses thereof are also provided. Compared to conventional arts, the extract has safety greatly improved and drug actions maintained and even improved.
Claims7
An extract for preventing or treating thrombotic diseases, produced by a process comprising following steps of:
- (1) cleaning a raw material comprising leeches and earthworms, with water for injection or normal saline, steeping at low temperature and filtrating to gain filtrate and dregs respectively;
- (2) mixing smashed dregs with filtrate which is obtained in said step (1) to produce homogenate, freezing and melting repeatedly and centrifuging the homogenate to obtain supernate;
- (3) ultrafiltrating the supernate which is obtained in said step (2) with ultrafiltration membrane or ultrafiltration column which is able to stay materials with molecular weights of between 10,000 and 100,000 daltons to obtain filtrate;
- and
- (4) filtrating the filtrate which is obtained in said step (3) with ultrafiltration membrane or ultrafiltration column which is able to stay materials with molecular weight of no more than 6,000 daltons,
- wherein said extract has components having molecular weights less than 5,800 daltons and comprises 15% to 38% amino acid, 40% to 60% saccharine and 0.3% to 1% hypoxanthine based on weight after dehydration and drying.
Dependencies are inferred from the claim text.