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US 2013/0171728 A1Published application
Interleukin-1 Alpha Antibodies and Methods of Use
AssigneeXbiotech, Inc.
InventorJohn Simard
Life of this patent
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Abstract
Fully human monoclonal Abs includes (i) an antigen-binding variable region that exhibits very high binding affinity for IL-1α and (ii) a constant region that is effective at both activating the complement system though C1q binding and binding to several different Fc receptors.
Claims2
A method of inhibiting migration of a cell through a basement membrane matrix, the method comprising the step of adding a purified monoclonal antibody (mAb) that specifically binds to human interleukin-1alpha (IL-1α) to a mixture comprising the basement membrane matrix and the cell.
Dependencies are inferred from the claim text.