Synthesis of new sialooligosaccharide derivatives

Compounds of general formula 1A′ and salts thereof

• wherein one of the R groups is an α-sialyl moiety and the other is H, is a protecting group that is removable by hydrogenolysis, A is a D-glucopyranosyl unit optionally substituted with fucosyl, integer m is 0 or 1, and X1 represents a carbohydrate linker, provided that 1-O-β-benzyl and 1-O-β-(4,5-dimethoxy-2-nitro)-benzyl glycosides of 3′-O—(N-acetyl-neuraminosyl)-lactose sodium salt, and 1-O-β-benzyl glycoside of 6′-O—(N-acetyl-neuraminosyl)-lactose sodium salt are excluded.

Compounds of general formula 2A′ and salts thereof

• wherein A is a D-glucopyranosyl unit optionally substituted with fucosyl, X1 represents a carbohydrate linker, integer m is 0 or 1, provided that a) when m is 0, then group A is substituted with fucosyl, and b) 1-O-β-benzyl-LNT, 1-O-β-(4-hydroxymethylbenzyl)-LNnT and 1-O-β-benzyl-LNnT are excluded.