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US 2013/0171694 A1Published application
Dna element having the activity of enhancing foreign gene expression
AssigneeDaiichi Sankyo Company, Limited
InventorsDaisuke Nishimiya, Tatsuya Inoue
Life of this patent
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Abstract
Disclosed is a method for stably achieving high expression of a foreign gene in mammalian cells using a novel DNA element. More specifically disclosed is a DNA element which enhances the activation of transcription by changing the chromatin structure around a gene locus into which a foreign gene expression unit has been introduced.
Claims23
A polynucleotide consisting of a sequence selected from the group consisting of SEQ ID NO:
- 1, SEQ ID NO:
- 2, SEQ ID NO:
- 3, SEQ ID NO:
- 4, and SEQ ID NO:
- 5.
2 more elements
2-5. (canceled)
A polynucleotide comprising at least 1500 consecutive nucleotides of a polynucleotide sequence of any one of SEQ ID NOS:
- 1 to 5.
(canceled)
Dependencies are inferred from the claim text.