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US 2013/0171680 A1Published application
Chimeric avian-based screening system containing mammalian grafts
AssigneesMedical Research Fund of Tel Aviv Sourasky Medical Center, Bar-Ilan University
InventorsRon Goldstein, Tamar Tennenbaum, Varda Deutsch
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Abstract
The present invention relates to animal model systems comprising a chimera between an avian embryo and a mammalian organism. Specifically, chimeric model systems comprising normal, diseased or genetically transformed mammalian cells and tissues transplanted into avian embryos, and uses thereof for in vivo testing of drugs and therapeutic modalities are disclosed.
Claims14
1-75. (canceled)
A method for screening anti-cancer drugs, comprising:
- a) engrafting a population of malignant mammalian hematopoietic cells into an avian egg;
- b) exposing the hematopoietic cells to at least one test drug;
- and
- c) analyzing the population of engrafted cells after a determined period of time.
1 more element
Dependencies are inferred from the claim text.