Diagnosis and monitoring of inflammation, ischemia and appendicitis
OwnerDavid Bar-Or, Raphael Bar-Or +2inventors
InventorsDavid Bar-Or, Raphael Bar-Or, James V. Winkler, Richard L. Yukl
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Abstract
The invention provides methods and kits for diagnosing and monitoring inflammation and/or ischemia in an animal. The methods comprise determining the quantity of a post-translationally modified protein, other than phosphorylated tau, present in a body fluid from an animal. The invention also provides an improved method and kits for diagnosing appendicitis in an animal. The method comprises determining the quantities of orthohydroxyhippuric acid and of a marker of general inflammation, such as a post-translationally modified protein, present in one or more body fluids of the animal.
Claims39
-61. (canceled)
A method of diagnosing or monitoring cardiac ischemia in an animal comprising:
- (a) determining the quantity of phosphorylated troponin I present in a body fluid of the animal;
- and
- (b) determining if the quantity of phosphorylated troponin I is significantly altered compared to a normal quantity in the same body fluid to determine if ischemia is present.
-80. (canceled)
-191. (canceled)
A kit comprising:
- a container holding a binding partner specific for post-translationally modified troponin I;
- and
- instructions directing that the binding partner is to be used to determine the quantity of the post-translationally modified troponin I present in a body fluid of an animal in order to diagnose or monitor cardiac ischemia.
-201. (canceled)
-274. (canceled)
A method of diagnosing or monitoring acute coronary syndrome (ACS) in an animal, comprising:
- (a) determining the quantity of a phosphorylated troponin I present in a body fluid of the animal in the first 12-24 hours after the onset of symptoms;
- and
- (b) determining if the quantity of the phosphorylated troponin I is significantly altered compared to a normal quantity in the same body fluid to determine if ACS is present in the first 12-24 hours after the onset of symptoms.
A kit comprising:
- a container holding a binding partner specific for a phosphorylated troponin I;
- a container holding a phosphatase inhibitor;
- and
- instructions directing that the binding partner is to be used to determine the quantity of the phosphorylated troponin I present in a body fluid of an animal, including a human, in the first 12-24 hours after the onset of symptoms for the method of claim 1.
Dependencies are inferred from the claim text.