Methods and compositions for treating neurodegenerative disorders and alzheimer's disease and improving normal memory
AssigneeThe Regents of the University of California
InventorsNazneen Dewji, S. Jonathan Singer
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Abstract
The disclosure relates generally to neurodegenerative disorders and more specifically to a group of presenilin/G-protein/c-src binding polypeptides and methods of use for modulating signaling and progression of Alzheimer's disease.
Claims4
A method of inhibiting the production of Aβ by contacting a cell expressing PS-1 and/or PS-2 with an agent that inhibits the interaction of PS-1 and/or PS-2 with GoA and GoB.
A method of inhibiting the production of Aβ by contacting a cell expressing a PS-1 and/or PS-2 with an agent that interferes with the downstream results of PS-1 and/or PS-2 binding to Go such as Go activation with phospholipase C.
A method of assaying for inhibitors of Alhzeimer's Disease progression comprising contacting a cell system comprising a first cell expressing βAPP and a second cell expressing PS-1 and/or PS-2 with an agent and measuring the activity of (a) Src family of tyrosine kinases, (b) GoA and/or GoB interaction with PS-1 and/or PS-2, and/or (c) the interaction of N-terminal domain of βAPP with the N-terminal domain of PS-1 and/or PS-2.
Dependencies are inferred from the claim text.