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US 2013/0171657 A1Published application
Rapid screening of biologically active nucleases and isolation of nuclease-modified cells
AssigneeSangamo BioSciences, Inc.
InventorsYannick Doyon, Michael C. Holmes, Tianjian Li
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Abstract
Disclosed herein are methods and compositions for rapidly identifying active nucleases and cells having nuclease-mediated genomic modifications.
Claims17
An episomal reporter construct comprising at least one target sequence for a nuclease comprising a TAL-effector domain, the target site flanked by sequences encoding a reporter gene.
Dependencies are inferred from the claim text.