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US 2013/0171461 A1Published application
Methods for synthesis of polymacromolecules and polymacromolecular brushes
AssigneeThe Trustees of Columbia University in the City of New York
InventorsBenjamin I. Dach, Jeffrey T. Koberstein, Nicholas J. Turro
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Abstract
In one aspect, the present invention is directed to methods for fabricating multilayer polymacromer compositions. In some embodiments, the multilayer polymacromer compositions described herein can comprise heterobifunctional macromolecules and heterotrifunctional molecules.
Claims27
A method for generating a multilayer polymacromer composition, the method comprising:
- (a) functionalizing a substrate with a primer surface group to form a functionalized substrate layer,
- (b) covalently linking a linker to the primer surface group, wherein the linker comprises a photocleavable functionality and a click moiety terminus,
- (c) forming a monomolecular layer by contacting the click moiety terminus of the linker with a first heterobifunctional macromolecule comprising a polymer backbone, a first click moiety terminus and a protected second click moiety terminus,
- (d) deprotecting the protected second click moiety terminus to form a functionalized monomolecular layer and,
- (e) forming a second monomolecular layer by contacting the functionalized monomolecular layer with a second heterobifunctional macromolecule comprising a polymer backbone, a first click moiety terminus and a protected second click moiety terminus, or a first heterotrifunctional branch comprising a first click moiety group and at least two protected second click moiety groups.
2 more elements
A method for generating a multilayer polymacromer composition, the method comprising:
- (a) functionalizing a substrate with a primer surface group, wherein the primer comprises a silicon and an amine group, to form a functionalized substrate layer,
- (b) covalently linking a linker to the primer surface group, wherein the linker comprises a nitrobenzyloxy carbonyl functionality and a click moiety terminus,
- (c) forming a monomolecular layer by contacting the click moiety terminus of the linker with a first heterobifunctional macromolecule comprising a α-trimethylsilyl alkynyl-ω-azido-poly(tert-butyl acrylate),
- (d) deprotecting the α-trimethylsilyl alkynyl terminus to form a functionalized monomolecular layer and,
- (e) forming a second monomolecular layer by contacting the alkyne terminus of the first monomolecular layer with a second heterobifunctional macromolecule comprising a α-trimethylsilyl alkynyl-ω-azido-poly(tert-butyl acrylate).
2 more elements
A multilayer polymacromer composition comprising:
- (a) a first terminus comprising a nitrophenyl functionality, and
- (b) n-layers, wherein each layer comprises a poly(tert-butyl acrylate) macromolecule, and wherein n is an integer between 1 and 100.
Dependencies are inferred from the claim text.