Methods and compositions for treatment of mitochondrial toxicity
AssigneeCardero Therapeutics, Inc.
InventorsFrancisco Villarreal, Alan Maisel, George Schreiner, Guillermo M. Ceballos Reyes, Pam Taub
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Abstract
The present invention relates to compositions and methods for prophylactic and/or therapeutic treatment of conditions related to mitochondrial function. In various aspects, the present invention comprises administering one or more compounds selected from the group consisting of epicatechin, an epicatechin derivative, catechin, a catechin derivative, nicorandil, and a nicorandil derivative in an amount effective to ameliorate mitochondrial toxicity caused by administration of a chemical, food, or drug.
Claims19
A method of ameliorating the effects of a chemical composition which causes a perturbation in mitochondrial number, function, or structure in a subject, comprising:
- administering an effective amount of one or more compounds selected from the group consisting of epicatechin, an epicatechin derivative, catechin, a catechin derivative, nicorandil, and a nicorandil derivative to said subject.
A pharmaceutical composition comprising a chemical composition which causes a perturbation in mitochondrial number, function, or structure when administered to a subject, and one or more compounds selected from the group consisting of epicatechin, an epicatechin derivative, catechin, a catechin derivative, nicorandil, and a nicorandil derivative.
A pharmaceutical composition comprising one or more compounds selected from the group consisting of epicatechin, an epicatechin derivative, catechin, a catechin derivative, nicorandil, and a nicorandil and one or more compounds selected from the group consisting of an antipsychotic, olanzepine, clozapine, risperidone, quetiapnie, a nucleoside reverse transcriptase inhibitor, zidovudine, bupivacaine, lidocaine, thiazolidinediones, doxorubicin, sorafenib, daunorubicin, epirubicin, idarubicin, celecoxib, diclofenac, ibuprofen, indomethacin, mefenamic acid, meloxicam, naproxen, piroxicam, sulindac, atenolol, pioglitazone, rosiglitazone, isoniazid, valproic acid, tamoxifen, flutamide, lamivudine, zalcitabine, phenoformin, metformin, nefazodone, abacavir, didanosine, nevirapine, tenofovir, stavudine, ketoconazole, divalproex sodium, cysplatin, gentamicin, a cyclosporin, ifosfamide, a statin, tenofovir, metformin, a corticosteroid, cortisol, prednisone, dexamethasone, triamcinalone, prednisolone, an inotrope, epinephrine, isoproterenol, a fibrate, clofibrate, gemfibrizole, cyprofibrate, and bezafibrate.
Use of one or more compounds selected from the group consisting of epicatechin, an epicatechin derivative, catechin, a catechin derivative, nicorandil, and a nicorandil derivative for ameliorating a perturbation in mitochondrial number, function, or structure induced by a chemical composition administered to a subject.
Dependencies are inferred from the claim text.