Formulation Comprising a Type B Lantibiotic

A pharmaceutical formulation of a capsule for oral delivery of a type B lantibiotic to the stomach comprising:

• a rapidly disintegrating capsule;
• a type B lantibiotic of formula (I):
• wherein
• X1-X2 is selected from the group consisting of Leu-Leu, Leu-Ile, Leu-Val, Ile-Leu, Ile-Ile, Ile-Val, Val-Ile and Val-Leu;
• X is —NH(CH2)qNH2;
• q is an integer 2 to 12;
• Z is —NR1R2;
• R1 is H or C1-4 alkyl,
• R2 is H, an amino acid or C1-4 alkyl, and
• p is 0 or 1, or
• a pharmaceutically acceptable salt or solvate thereof,
• wherein the capsule releases the type B lantibiotic into the stomach.