Stable pharmaceutical composition and methods of using same
AssigneeAmarin Pharmaceuticals Ireland Limited
InventorsMehar Manku, Ian Osterloh, Pierre Wicker, Rene Braeckman, Paresh Soni
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Abstract
The present invention relates to, inter alia, pharmaceutical compositions comprising a polyunsaturated fatty acid and to methods of using the same to treat or prevent cardiovascular-related diseases.
Claims26
A method of reducing triglycerides comprising, identifying a group of subjects having a median triglyceride level of at least 500 mg/dl and orally administering daily to at least one subject in the group of subjects about 2500 mg to about 5000 mg of ethyl eicosapentaenoate, present in one or more capsules, wherein upon 12 weeks of said administering the at least one subject exhibits a reduction in triglycerides without an increase of LDL-C of more than 5%.
A method of reducing triglycerides comprising, identifying a group of subjects having a median triglyceride level of at least 500 mg/dl and orally administering daily to at least one subject in the group 4 capsules, each capsule comprising about 900 mg to about 1 g of ethyl eicosapentaenoate, wherein upon 12 weeks of said administering the at least one subject exhibits a reduction in triglycerides without an increase of LDL-C of more than 5%.
A method of reducing triglycerides comprising, identifying a group of subjects having a median triglyceride level of at least 500 mg/dl, orally administering daily to at least one subject in the group about 4 g of fatty acids, at least about 90% by weight of which are ethyl eicosapentaenoate, wherein upon 12 weeks of said administering the at least one subject exhibits a reduction in triglycerides without an increase of LDL-C of more than 5%.
Dependencies are inferred from the claim text.