Prevention and Treatment of Ischemia-Reperfusion Injury and Related Conditions
AssigneesMedical University of South Carolina, The Regents of the University of Colorado, a body corporate
InventorsVernon Michael Holers, Liudmila Kulik, George C. Tsokos, Stephen Tomlinson
Life of this patent
Estimating the term…
Abstract
Disclosed are lipids, annexin, and lipid-annexin complexes for use in the prevention and/or treatment of ischemia-reperfusion injury and reperfusion injury associated with a variety of diseases and conditions. Also disclosed are therapeutic targets and compositions for the prevention and treatment of ischemia-reperfusion injury and diseases and conditions associated with ischemia-reperfusion injury.
Claims33
A method to prevent or treat ischemia-reperfusion injury in an individual, comprising administering to the individual an agent that blocks or inhibits the binding of natural antibodies in the individual to:
- a) annexin-4 expressed on the surface of a cell that is in or adjacent to a tissue that is undergoing, or is at risk of undergoing, ischemia-reperfusion injury;
- and/or
- b) a phospholipid expressed on the surface of a cell that is in or adjacent to a tissue that is undergoing, or is at risk of undergoing, ischemia-reperfusion injury.
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
A method to prevent or treat ischemia-reperfusion injury in an individual, comprising administering to the individual a liposome or stable lipid moiety comprising one or more phospholipids.
(canceled)
(canceled)
A method to prevent or treat ischemia-reperfusion injury in an individual, comprising administering to the individual an isolated annexin-4 protein or biologically active homologue thereof that binds to a phospholipid or comprises at least one conformational epitope bound by a natural antibody in the individual.
31-34. (canceled)
36-69. (canceled)
Dependencies are inferred from the claim text.