Compositions and methods for inducing immune tolerance
AssigneeThe Scripps Research Institute
InventorsJames C. Paulson, Matthew MacAuley, David Nemazee
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Abstract
The present invention provides liposomal compositions for inducing immune tolerance. The compounds typically comprise a liposome displaying a specific antigen and also a binding moiety for a sialic acid binding Ig-like lectin (Siglec) expressed on B cells. The invention also provides methods for inducing tolerance to a protein or polypeptide antigen (e.g., a protein antigen) in a subject. The methods involve administering to the subject a pharmaceutical composition that co-presents both the antigen and a glycan ligand for a Siglec expressed on B lymphocytes.
Claims25
A liposomal composition for inducing immune tolerance to an antigen, comprising a liposome nanoparticle displaying the antigen and a binding moiety for a sialic acid binding Ig-like lectin (Siglec).
A method for inducing tolerance to a polypeptide antigen in a subject, comprising administering to the subject a pharmaceutical composition comprising an effective amount of the antigen and a Siglec ligand, thereby inducing immune tolerance to the antigen.
A method for suppressing or preventing an undesired immune response to a specific antigen in a subject, comprising administering to the subject a pharmaceutical composition comprising a liposome composition displaying the antigen and a ligand for a sialic acid binding Ig-like lectin (Siglec).
Dependencies are inferred from the claim text.