Implantable polymeric device for sustained release of buprenorphine
AssigneeTitan Phamaceuticals, Inc.
InventorsRajesh A. PATEL, Louis R. BUCALO
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Abstract
The present invention provides compositions, methods, and kits for treatment of opiate addiction and pain. The invention provides a biocompatible nonerodible polymeric device which releases buprenorphine continuously with generally linear release kinetics for extended periods of time. Buprenorphine is released through pores that open to the surface of the polymeric matrix in which it is encapsulated. The device may be administered subcutaneously to an individual in need of continuous treatment with buprenorphine.
Claims19
1-55. (canceled)
A method for treating opioid addiction in a human in need thereof, the method comprising subcutaneously implanting into the human at least one implantable device comprising buprenorphine and a polymer matrix, wherein the buprenorphine is released from the implantable device at a rate that results in a therapeutically-effective plasma level in the human of about 0.1 ng/ml to about 70 ng/ml.
An implantable device comprising:
- a) a polymer matrix;
- and
- b) buprenorphine,
- wherein upon implantation of the device in a human, the device releases buprenorphine at a rate that results in a therapeutically effective plasma level in the human of about 0.1 ng/ml to about 70 ng/ml.
Dependencies are inferred from the claim text.