Treatment of biofilms
OwnerSteven Lane Percival, Brian John Hamerslaginventors
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Abstract
The combination of a first species which is a polyanionic compound and a second species which is an antimicrobial agent is used for the treatment of microbial biofilms and for the topical treatment of wounds. The combination may be incorporated in a wound dressing. The polyanionic compound may be a polyphosphate, such as an alkali metal polyphosphate, e.g. sodium hexametaphosphate. Examples of antimicrobial agents include metallic silver, silver compounds, iodine, PHMB (polyhexamethylene biguanide), acetic acid, chlorhexidine, aminoglycosides (e.g. amikacin, gentamicin, streptomycin and tobramycin), ansamycins, carbacephem, cephalosporins, glycopeptides (e.g. vancomycin), macrolides (eg clarithromycin), monobactams and sulfonamides).
Claims27
The combination of a first species which is a polyphosphate and a second species which is an antimicrobial agent for the treatment of microbial biofilms or for the topical treatment of wounds.
-4. (canceled)
-9. (canceled)
A topically administrable wound treatment composition comprising a first species which is a polyphosphate and a second species which is an antimicrobial agent.
(canceled)
A method of inhibiting a wound infection, comprising administering to the wound a first species which is a polyphosphate and a second species which is an antimicrobial agent other than a polyanionic compound.
A method as claimed in 28 for inhibiting, reducing, removing biofilm on a wound.
A method as claimed in 28 effected using a composition comprising said polyphosphate and said antimicrobial agent.
The combination of a polyphosphate and an antimicrobial species for the treatment of microbial biofilms.
Dependencies are inferred from the claim text.