Compositions of nanoparticles and methods of making the same
AssigneeJeffrey W Smith
InventorsJeffrey W. Smith, Hui Xie
Life of this patent
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Abstract
Disclosed herein are compositions of nanoparticles. In some embodiments, the nanoparticles are Janus particles, where each particle includes a first component and second component that are exposed to the surface of the particle. Also, disclosed are methods and systems for making a composition of nanoparticles. Finally, a method of treating a mammal by administering a composition of nanoparticles is disclosed.
Claims40
A method of making Janus particles, comprising:
- (a) providing at least a first liquid feed stream and a second liquid feed stream;
- and (b) intermixing the first liquid feed stream and the second liquid feed stream with a dispersing stream, thereby solidifying components of the first liquid feed stream and the second liquid feed stream into a plurality of Janus particles dispersed in the dispersing stream, wherein:
- the first liquid feed stream comprises a first polymer and the second liquid feed stream comprises a second component that is substantially different from the first polymer;
- and at least a portion of the Janus particles comprise the first polymer and the second component.
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A composition comprising a plurality of Janus particles, each Janus particle comprising:
- a first component comprising a first polymer;
- and a second component that is substantially different from the first component, wherein:
- the Janus particles have an average size in the range of about 10 nm to about 2000 nm;
- and at least part of the first component and at least part of the second component are exposed at an outer surface of the Janus particle.
A system for making a plurality of Janus particles, comprising:
- a first feed channel;
- a second feed channel;
- and a dispersing channel, wherein:
- the first feed channel has a first outlet that is operably connected to the dispersing channel;
- the second feed channel has a second outlet that is operably connected to the dispersing channel;
- the first outlet and the second outlet are no more than about 5 mm apart;
- and the first outlet and the second outlet are within about 1 mm of the dispersing channel;
- and the first feed channel has a first diameter in the range of about 10 μm to about 1 mm;
- the second feed channel has a second diameter in the range of about 10 μm to about 1 mm;
- and the dispersing channel has a third diameter that is at least 2 times larger than the first diameter.
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Dependencies are inferred from the claim text.