Composition And Methods For Antimicrobial Articles
OwnerSolomon Rosenblatt, John P. Kennedy +1inventors
InventorsSolomon Rosenblatt, John P. Kennedy, Curtis E. Jones
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Abstract
A biocompatible controlled release form of complexed iodine is achieved by a complexation of polyvinyl alcohol based foam and characterized by a residual starch component to optimize iodine release profiles. The resulting iodine complexed polyvinyl alcohol foam may be utilized locally as an antimicrobial agent that releases controlled amounts of iodine sufficient to kill microbes for extended durations without excessive bulk and rigidity.
Claims29
A PVA foam article comprising:
- a) at least in part a pore forming carbohydrate, and
- b) iodine complexed at least in part to the PVA, where the pre-iodine complexed density of the PVA foam is at least 0.074 g/cm3.
A method of producing an iodine complexed PVA foam article with a pore forming carbohydrate comprising:
- a) mixing PVA resin, a carbohydrate pore former, and water,
- b) polymerizing at least some of the PVA resin within the mixture,
- c) curing the resulting polymerized PVA within the mixture,
- d) removing a portion of the carbohydrate thereby creating a PVA foam with a density of at least 0.074 g/cm3, and
- e) complexing the PVA foam and residual carbohydrate with iodine.
A method of treating a wound comprising:
- a) providing a PVA foam sponge with a density of at least 0.074 g/cm3,
- b) complexing the PVA foam with iodine, and
- c) applying the PVA foam sponge to the wound bed, where the complexed PVA foam sponge exhibits the controlled in vitro cumulative release of iodine in distilled water at 37 C at or near sink conditions of:
- i. between 50 ppm and 175 ppm at 3 hours,
- ii. between 100 ppm and 300 ppm at 6 hours, and
- iii. between 180 ppm and 400 ppm at 12 hours.
Dependencies are inferred from the claim text.