Immunomodulatory Compounds for the Restoration of Vitamin D Sensitivity in Vitamin D Resistant Tumor Cells
AssigneeCelgene Corporation
InventorsCarole Brosseau, Justin Blake Bartlett, Angus George Dalgleish, Kay Winifred Colston, Christine Galustian
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Abstract
Provided herein are methods of restoring vitamin D sensitivity in tumor cells that are vitamin D resistant. Also provided are methods of treating, preventing or managing cancer using an immunomodulatory compound in combination with a vitamin D agent. Pharmaceutical compositions and single unit dosage forms suitable for use in the methods provided herein are also disclosed.
Claims20
A method of restoring vitamin D sensitivity in a vitamin D resistant tumor cell comprising contacting the tumor cell with an immunomodulatory compound.
A method of treating, managing or preventing cancer refractory to vitamin D treatment, which comprises administering to a patient having such cancer an amount of an immunomodulatory compound, or a pharmaceutically acceptable salt, solvate, or stereoisomer thereof, in combination with a vitamin D agent.
A pharmaceutical composition comprising an immunomodulatory compound, or a pharmaceutically acceptable salt, solvate, or stereoisomer thereof, and a vitamin D agent.
Dependencies are inferred from the claim text.