Lentiviral vector based immunological compounds against malaria
OwnerPierre Charneau, Frederic Philippe Coutantinventors
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Abstract
The invention relates to lentiviral vector particles pseudotyped with a determined heterologous viral envelope protein or viral envelope proteins originating from a RNA virus and which comprise in its genome at least one recombinant polynucleotide encoding at least one polypeptide(s) carrying epitope(s) of an antigen of a Plasmodium parasite capable of infecting a mammalian host. The lentiviral vector particles are used in order to elicit an immunological response against malaria parasites.
Claims23
1-22. (canceled)
A lentiviral vector particle (i) which is pseudotyped with at least one determined heterologous viral envelope protein originating from a RNA virus and (ii) which comprises in its genome at least one recombinant polynucleotide encoding at least one polypeptide comprising at least one epitope of a pre-erythrocytic stage antigen of a Plasmodium parasite capable of infecting a mammalian host.
Dependencies are inferred from the claim text.