Therapeutic vaccination against active tuberculosis
AssigneeCrucell Holland B.V.
InventorsJerald Sadoff, Anisah Alyahya
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Abstract
The invention provides a method for therapeutic treatment of a patient having active tuberculosis (TB), the method comprising: administering to the patient a recombinant adenovirus vector that comprises nucleic acid encoding the Ag85A, Ag85B and TB10.4 antigens of Mycobactium tuberculosis (Mtb). Advantageously, the method can be used to shorten conventional drug therapy for treating active TB.
Claims21
-21. (canceled)
A method for treating a patient having active tuberculosis (TB), the method comprising:
- administering to the patient a recombinant adenovirus vector comprising nucleic acid encoding Ag85A, Ag85B and TB10.4 antigens of Mycobacterium tuberculosis (Mtb).
A method for inducing an immune response against antigens of Mycobacterium tuberculosis (Mtb) in a subject infected with Mtb, the method comprising:
- administering to the subject a recombinant adenovirus vector comprising nucleic acid encoding Ag85A, Ag85B, and TB10.4 antigens of Mtb to express said antigens and to induce an immune response to at least one of the antigens in the subject.
Dependencies are inferred from the claim text.