Norovirus derived immunogenic compositions and methods
OwnerEthan Settembre, Angelica Medina-Selby +2inventors
InventorsEthan Settembre, Angelica Medina-Selby, Doris Coit, Philip R. Dormitzer
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Abstract
The invention relates to chimeric norovirus VP1 proteins containing the S-domain of VP1 of a first norovirus strain and a P-domain that contains at least a portion of the P-domain of VP1 of a second norovirus strain. The invention also relates to nucleic acids that encode the chimeric VP1 proteins, virus-like particles that contain a chimeric norovirus VP1 protein, and to immunogenic compositions.
Claims45
A chimeric norovirus viral protein 1 (VP1) comprising the S-domain of the VP1 from a first norovirus strain and at least a portion of the P-domain of the VP1 from a second norovirus strain.
Dependencies are inferred from the claim text.