Antibodies and immunoconjugates and uses therefor
AssigneeGenentech, Inc.
InventorsALLEN J. EBENS, JR., ALANE M. GRAY, WEI-CHING LIANG, YAN WU, SHANG-FAN YU
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Abstract
Anti-CD22 antibodies and immunoconjugates thereof are provided. Methods of using anti-CD22 antibodies and immunoconjugates thereof are provided.
Claims13
1-238. (canceled)
A variable domain of an anti-CD22 antibody comprising a heavy chain variable domain amino acid sequence of SEQ ID NO:
- 16.
A variable domain of an anti-CD22 antibody comprising a light chain variable domain amino acid sequence of SEQ ID NO:
- 18.
An anti-CD22 antibody comprising the heavy chain variable domain sequence of SEQ ID NO:
- 18 and the light chain variable domain sequence of SEQ ID NO:
- 16.
An anti-CD22 antibody having a variable light chain comprising a HVR-L1 having the sequence of SEQ ID NO:
- 10, a HVR-L2 having the sequence of SEQ ID NO:
- 12, and a HVR-L3 having the sequence of SEQ ID NO:
- 14.
An anti-CD22 antibody having a variable heavy chain comprising a HVR-H1 having the sequence of SEQ ID NO:
- 2, a HVR-H2 having the sequence of SEQ ID NO:
- 4, and a HVR-H3 having the sequence of SEQ ID NO:
- 6.
A polypeptide comprising the amino acid sequence of SEQ ID NO:
- 16.
A polypeptide comprising the amino acid sequence of SEQ ID NO:
- 18.
Dependencies are inferred from the claim text.