Compositions and methods for the prevention of oxidative degradation of proteins
OwnerJunyan A. Ji, Yuchang John Wang +1inventors
InventorsJUNYAN A. JI, Yuchang John Wang, Boyan Zhang
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Abstract
The invention relates to pharmaceutical formulations comprising a protein and free methionine in combination with one or more compounds capable of preventing the oxidation of aromatic amino acid residues within a protein. More specifically, the invention relates to stabilized, pharmaceutically effective preparations of oxidation-sensitive therapeutic agents. The invention further relates to a method of inhibiting the oxidation of such therapeutic agents.
Claims32
A pharmaceutical formulation comprising a protein, free methionine and one or more compounds capable of preventing the oxidation of aromatic amino acid residues within said protein.
A method of stabilizing a pharmaceutical composition of a protein which comprises adding methionine and one or more compounds to said composition in an amount sufficient to inhibit oxidation of aromatic amino acid residues within said protein.
A method of making a pharmaceutical formulation comprising adding an amount of a surfactant to a protein composition and an amount of a compound sufficient to negate the oxidative species generated from the degradation of said surfactant.
A method of preventing the oxidation of aromatic amino acid residues within a susceptible protein which comprises adding methionine in combination with one or more compounds selected from the group consisting of aromatic amino acids, nucleotides, and vitamins or their derivatives.
Dependencies are inferred from the claim text.