Antibodies to muc16 and methods of use thereof
AssigneeMemorial Sloan Kettering Cancer Center
InventorsDavid Spriggs, Dharmarao Thapi
Life of this patent
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Abstract
The invention provides antibodies, and antigen-binding fragments thereof, that specifically bind to a polypeptide, or antigenic portion thereof, wherein the polypeptide is selected from a) MUC16 ectodomain polypeptide, b) MUC16 cytoplasmic domain polypeptide, and c) MUC16 extracellular domain polypeptide that contains a cysteine loop polypeptide. The invention's antibodies and compositions containing them are useful in diagnostic and therapeutic applications for diseases in which MUC16 is overexpressed, such as cancer.
Claims34
An isolated antibody, or an antigen-binding fragment thereof, that specifically binds to a polypeptide or to an antigenic portion thereof, wherein the polypeptide is selected from the group consisting of
- (SEQ ID NO:
- 02)
- a) TLDRSSVLVDGYSPNRNE,
- (SEQ ID NO:
- 03)
- b) CGVLVTTRRRKKEGEYNVQQQ,
- (SEQ ID NO:
- 21)
- c) TLDRKSVFVDGYSQNRDD,
- (SEQ ID NO:
- 22)
- d) KSYFSDCQVLAFRSVSNNNNHTGVDSLCNFSPL,
- and
- (SEQ ID NO:
- 23)
- e) SLYSNCRLASLRPKKNGTATGVNAICSYHQN.
A hybridoma cell that produces an antibody, or an antigen-binding fragment thereof, that specifically binds to a polypeptide or to an antigenic portion thereof, wherein the polypeptide is selected from the group consisting of
- (SEQ ID NO:
- 02)
- a) TLDRSSVLVDGYSPNRNE,
- (SEQ ID NO:
- 03)
- b) CGVLVTTRRRKKEGEYNVQQQ,
- (SEQ ID NO:
- 21)
- c) TLDRKSVFVDGYSQNRDD,
- (SEQ ID NO:
- 22)
- d) KSYFSDCQVLAFRSVSNNNNHTGVDSLCNFSPL,
- and
- (SEQ ID NO:
- 23)
- e) SLYSNCRLASLRPKKNGTATGVNAICSYHQN.
An isolated nucleotide sequence comprising a polynucleotide that encodes at least one of a variable heavy (VH) chain sequence and the variable light (VL) chain sequence of an antibody that specifically binds to a polypeptide, wherein the polypeptide is selected from the group consisting of
- (SEQ ID NO:
- 02)
- a) TLDRSSVLVDGYSPNRNE,
- (SEQ ID NO:
- 03)
- b) CGVLVTTRRRKKEGEYNVQQQ,
- (SEQ ID NO:
- 21)
- c) TLDRKSVFVDGYSQNRDD,
- (SEQ ID NO:
- 22)
- d) KSYFSDCQVLAFRSVSNNNNHTGVDSLCNFSPL,
- and
- (SEQ ID NO:
- 23)
- e) SLYSNCRLASLRPKKNGTATGVNAICSYHQN.
A method for producing an antibody that specifically binds to a polypeptide or to an antigenic portion thereof, comprising administering to a subject an immunologically effective amount of a polypeptide selected from the group consisting of
- (SEQ ID NO:
- 02)
- a) TLDRSSVLVDGYSPNRNE,
- (SEQ ID NO:
- 03)
- b) CGVLVTTRRRKKEGEYNVQQQ,
- (SEQ ID NO:
- 21)
- c) TLDRKSVFVDGYSQNRDD,
- (SEQ ID NO:
- 22)
- d) KSYFSDCQVLAFRSVSNNNNHTGVDSLCNFSPL,
- and
- (SEQ ID NO:
- 23)
- e) SLYSNCRLASLRPKKNGTATGVNAICSYHQN.
Dependencies are inferred from the claim text.