Monoclonal antibodies against her2 epitope
AssigneeGenmab A/S
InventorsBart De Goeij, Edward Norbert Van Den Brink, Simone De Haij, Thilo Riedl, Rene Hoet, Ole Baadsgaard, David Satijn, Jan Van De Winkel, Paul Parren
Life of this patent
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Abstract
Isolated monoclonal antibodies which bind to human epidermal growth factor receptor 2 (HER2), and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and therapeutic and diagnostic methods for using the antibodies are also disclosed.
Claims49
An isolated antibody which blocks the binding of a reference antibody to soluble human epidermal growth factor receptor 2 (HER2), wherein the reference antibody comprises heavy chain variable (VH) and light chain variable (VL) regions selected from the group consisting of:
- a) a VH region comprising the sequence of SEQ ID NO:1 and a VL region comprising the sequence of SEQ ID NO:5;
- b) a VH region comprising the sequence of SEQ ID NO:8 and a VL region comprising the sequence of SEQ ID NO:12;
- c) a VH region comprising the sequence of SEQ ID NO:15 and a VL region comprising the sequence of SEQ ID NO:19;
- d) a VH region comprising the sequence of SEQ ID NO:22 and a VL region comprising the sequence of SEQ ID NO:26;
- e) a VH region comprising the sequence of SEQ ID NO:29 and a VL region comprising the sequence of SEQ ID NO:33;
- and
- f) a VH region comprising the sequence of SEQ ID NO:36 and a VL region comprising the sequence of SEQ ID NO:40;
- optionally when determined as described in Example 14.
An isolated antibody which comprises a VH region comprising a CDR3 sequence selected from the group consisting of
- a) SEQ ID NO:59;
- b) SEQ ID NO:62;
- c) SEQ ID NO:65;
- d) SEQ ID NO:67
- e) SEQ ID NO:4;
- f) SEQ ID NO:25;
- g) SEQ ID NO:32
- h) SEQ ID NO:11;
- i) SEQ ID NO:18;
- and
- j) SEQ ID NO:39.
An isolated human antibody which does not block the binding of a reference antibody to soluble HER2, wherein the reference antibody comprises the VH and VL sequences of the antibodies selected from the group consisting of trastuzumab, pertuzumab, F1, and C5.
A nucleotide sequence encoding one or more of the amino acid sequences selected from the group consisting of SEQ ID NO:
- 1, 5, 8, 12, 15, 19, 22, 26, 29, 33, 36, 40, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, and 56.
42-48. (canceled)
Dependencies are inferred from the claim text.