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AssigneesVanderbilt University, Oregon Health & Science University
InventorsAndras Gruber, Erik I. Tucker, Stephen Raymond Hanson, David Gailani
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The present invention relates to compositions and methods for inhibiting thrombosis without compromising hemostasis. Compositions include anti-factor XI monoclonal antibodies (aXIMabs) capable of binding to an epitope on the heavy chain of human FXI, particularly the A3 domain of the heavy chain of human FXI. Compositions also include epitope-binding fragments, variants, and derivatives of the monoclonal antibodies, cell lines producing these antibody compositions, and isolated nucleic acid molecules encoding the amino acid sequences of the antibodies. The invention further includes pharmaceutical compositions comprising the anti-factor XI monoclonal antibodies of the invention, or epitope-binding fragments, variants, or derivatives thereof, in a pharmaceutically acceptable carrier. Methods of the invention comprise administering the compositions described above to a subject in need thereof for the purpose of inhibiting thrombosis, reducing a required dose of an antithrombotic agent in the treatment of thrombosis, treating metastatic cancer, or treating an acute inflammatory reaction.
A method for treating a coagulopathy in a subject in need thereof, comprising administering to the subject a therapeutically effective dose of an anti-Factor XI (FXI) antibody or biologically active fragment thereof, wherein the antibody or biologically active fragment thereof comprises:
A method for treating metastatic cancer in a subject in need thereof, comprising administering to the subject a therapeutically effective dose of an anti-FXI antibody or biologically active fragment thereof, wherein the antibody or biologically active fragment thereof comprises:
A method for treating an acute inflammatory reaction in a subject in need thereof, comprising administering to the subject a therapeutically effective dose of an anti-FXI antibody or biologically active fragment thereof, wherein the antibody or biologically active fragment thereof comprises:
Dependencies are inferred from the claim text.