Back to results
US 2013/0171142 A1Published application
Methods of using anti-cd3 antibodies to prevent weight gain
OwnerAoife Brennan, Charlotte Mckee +2inventors
InventorsAoife Brennan, Charlotte Mckee, Lou Vaickus, Douglas Ringler
Life of this patent
Estimating the term…
Abstract
Provided herein are methods of administering anti-CD3 antibodies or antigen binding fragments to a human for decreasing weight gain or increasing weight loss. In certain embodiments, the human exhibits a body mass index (BMI) or greater than or equal to about 27. In certain embodiments, the anti-CD3 antibody or antigen binding fragment does not bind or has reduced binding to at least one class of Fc (gamma) receptor.
Claims27
A method of administering to a human an anti-CD3 antibody or anti-CD3 antigen binding fragment, the method comprising:
- selecting a human with a body mass index greater than or equal to about 27 in a dosing regimen;
- administering the antibody or antigen binding fragment to the selected human;
- wherein the amount of the antibody or antigen binding fragment administered on the first day of the dosing regimen is less than about 0.5 mg;
- wherein the antibody or antigen binding fragment does not bind or has reduced binding to at least one class of Fc (gamma) receptor compared to the IgG1 immunoglobulin molecule produced by the cell line ARH-77 deposited under ATCC catalog number CRL-1621.
1 more element
-55. (canceled)
Dependencies are inferred from the claim text.