Methods for the Regulation of Cellular Metabolism Through the Modulation of SIRT3 Activity
AssigneeNational Institutes of Health (NIH), U.S. Dept. of Health and Human Services (DDS), U.S. Government
InventorsMarcia C. Haigis, Lydia Finley
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Abstract
The present invention relates to methods of preventing or treating cancer and/or decreasing damage to organs or tissues exposed to hypoxic conditions through the use of agents that modulate the expression or activity of SIRT3.
Claims22
A method of reducing glycolysis in a cell comprising contacting said cell with an agent that increases the activity or expression of SIRT3 in said cell.
A method of increasing glycolysis in a cell comprising contacting said cell with an agent that decreases the activity or expression of SIRT3 in said cell.
18-66. (canceled)
A method of determining the metabolic phenotype of a tumor cell comprising the steps of:
- a) providing a tumor cell;
- and
- b) determining the level of SIRT3 protein or RNA in the tumor cell;
- wherein a decreased level of SIRT3 protein or RNA in the tumor cell relative to the level of SIRT3 protein or RNA in a non-tumor cell indicates that the tumor cell has a glycolytic phenotype.
68-69. (canceled)
Dependencies are inferred from the claim text.