Endopeptidase and neurotoxin combination treatment of bladder disorders
AssigneeAllergan, Inc.
InventorsGregory F. Brooks, Kenton B. Abel
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Abstract
The present specification discloses Clostridial neurotoxins and TEMs, compositions comprising such Clostridial neurotoxins and TEMs, kits comprising such Clostridial neurotoxins, TEMs and/or compositions, methods of treating a bladder disorder in an individual using such Clostridial neurotoxins, TEMs and/or compositions, use of such Clostridial neurotoxins and TEMs in manufacturing a medicament for treating a bladder disorder, and uses of such Clostridial neurotoxins, TEMs and/or compositions in treating a bladder disorder.
Claims4
A method of treating a bladder disorder in an individual, the method comprising the steps of:
- administering to the individual in need thereof a therapeutically effective amount of a first composition comprising a botulinum neurotoxin to a first treatment region;
- administering a therapeutically effective amount of a second composition including a targeted exocytosis modulator (TEM) to a second treatment region;
- wherein the TEM comprises a targeting domain, a Clostridial toxin translocation domain, a Clostridial toxin enzymatic domain, and an exogenous protease cleavage site, wherein the targeting domain is a sensory neuron targeting domain, a sympathetic neuron targeting domain, or a parasympathetic neuron targeting domain, wherein the first treatment region includes a lateral bladder wall region, a bladder dome region, or both,
- wherein the second treatment region includes a trigone region, a bladder base region, or both, and, wherein administration of the first and second compositions reduces a symptom of the bladder disorder, thereby treating the individual.
A kit for the treatment of a bladder disorder in an individual in need thereof comprising a first composition including a botulinum neurotoxin, and a second composition including a TEM, wherein the botulinum neurotoxin is administered to a lateral bladder wall region, a bladder dome region, or both;
- and the TEM is administered to a trigone region, a bladder base region, or both.
Dependencies are inferred from the claim text.