Use of anti third party central memory t cells for anti-leukemia/lymphoma treatment

2-4. (canceled)

10-11. (canceled)

(canceled)

An isolated population of cells comprising non-GVHD inducing anti-third party cells having a central memory T-lymphocyte (Tcm) phenotype, said cells being tolerance-inducing cells and capable of homing to the lymph nodes following transplantation, and further wherein said cells are either:

• (i) non-syngeneic with both a host subject and a graft, wherein said subject and said graft are non-syngeneic;
• or
• (ii) non-syngeneic with a graft and syngeneic with a host subject, wherein said subject and said graft are non-syngeneic.

A method of treating a disease in a subject in need thereof, the method comprising:

• (a) transplanting immature hematopoietic cells to the subject;
• and
• (b) administering to the subject a therapeutically effective amount of an isolated population of cells comprising non-graft versus host (GVHD) inducing anti-third party cells having a central memory T-lymphocyte (Tcm) phenotype, said cells being tolerance-inducing cells and capable of homing to the lymph nodes following transplantation, wherein when said immature hematopoietic cells are syngeneic with the subject, said isolated population of cells are selected syngeneic with the subject or non-syngeneic with the subject.

A method of treating a disease in a subject in need thereof, the method comprising:

• (a) transplanting immature hematopoietic cells to the subject;
• and
• (b) administering to the subject a therapeutically effective amount of an isolated population of cells comprising non-graft versus host (GVHD) inducing anti-third party cells having a central memory T-lymphocyte (Tcm) phenotype, said cells being tolerance-inducing cells and capable of homing to the lymph nodes following transplantation, wherein when said immature hematopoietic cells are non-syngeneic with the subject, said isolated population of cells are selected syngeneic with the subject or non-syngeneic with both the subject and said immature hematopoietic cells.

(canceled)

(canceled)

43-44. (canceled)

(canceled)